One of the world leaders in luxury cosmetics, French skincare brand Sisley recently introduced its new Sisleya L’Integral Anti-Age treatment that promises spectacular results.

“It is almost impossible for a brand to stop producing its best-selling product and our Global Anti-Age treatment, which we launched in 1999, has been our key success. Now thanks to our research into epigenetics, we have found something better,” Nicolas Chesnier, Sisley’s regional managing director for Asia Pacific, told XP during the recent launch at the Mandarin Oriental Hotel, which was attended by several of the brand’s loyal customers.

“Our extensive research has proved that behavioural ageing such as stress and the choices we make like smoking, overexposure to the sun or poor dietary habits mark the face even more than genetic ageing and are responsible for the majority of ageing overall.”

Combined with previously identified environmental factors such as UVA-UVB rays, pollution and free radicals, these factors deregulate the lifecycle of cells by modifying “cellular rhythm”, in which the cells protect themselves during the day, and repair themselves at night. Also affected are “cellular energy” which enables cells to function and renew correctly and “cellular longevity” which is determined by the length of the telomeres, the protective extremity of each chromosome, the length of which correlates with cellular life expectancy and preserves the integrity of the DNA. In a young person, this lifecycle is well organised and functional. However, in a more mature person or a person who has undergone various behavioural stresses, this cycle becomes “jammed,” and if only one of the three factors is affected, the whole cycle is disturbed. The consequences on the skin are premature visible signs of ageing including wrinkles, loss of radiance and firmness.

Among the many active ingredients added to the initial Sisleya formula, three major new ingredients now optimise the functioning of this lifecycle to protect the skin from the visible signs of behavioural ageing. These active ingredients target the three parts of the cells’ lifecycle to help compensate for their being weakened. Lindera extract helps to resynchronise the skin’s biorhythms, restoring the ideal rhythm of activity for younger skin to the cellular metabolism. Persian acacia extract promotes optimal energy production at the level of the cells (mitochondria) to protect against and repair skin damage caused by cellular fatigue while yeast and soya protein complex helps protect telomeres. It also helps to maintain the integrity of cellular DNA against behavioural stresses, for optimised cellular longevity.

Eight different clinical tests have been carried out with more than 300 women and the results show an improvement in the quality of the collagen network and the dermo-epidermal junction. This was examined using in vivo microscopy, which enables all of the layers of the skin to be viewed from the epidermis to the dermis so that all of major constituent parts can be measured and the quality of their structure characterised.