Science conference slams ‘deeply disturbing’ baby gene-editing claim

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Science conference slams ‘deeply disturbing’ baby gene-editing claim

Breaking News November 29, 2018 14:46

By Agence France-Presse
Hong Kong

A scientist who upended a Hong Kong conference with his claim to have created the world’s first genetically-edited babies cancelled a fresh talk and was heavily criticised by organisers Thursday, who labelled him as irresponsible.

He Jiankui had told a packed biomedical conference Wednesday he was “proud” to have successfully altered the DNA of twin girls born to an HIV-positive father, an apparent medical breakthrough.

But details of the experiment, which has not been independently verified, triggered an immediate backlash and He said the trial had been halted.

He was supposed to speak at the summit again Thursday but disappeared from the schedule.

David Baltimore, a Nobel laureate and chairman of the organising committee, told reporters it was He’s decision not to attend.

Organisers of the Second International Summit on Human Genome Editing denounced He’s “unexpected and deeply disturbing” claim that human embryos had been edited and implanted, and called for closer supervision of the field at the conclusion of the conference Thursday.

“Even if the modifications are verified, the procedure was irresponsible and failed to conform with international norms,” they said in a statement.

“Its flaws include an inadequate medical indication, a poorly designed study protocol, a failure to meet ethical standards for protecting the welfare of research subjects, and a lack of transparency in the development, review and conduct of clinical procedures,” it added.

University professor He, based in the southern Chinese city of Shenzhen, said the twin girls, born a few weeks ago, had their DNA altered to prevent them from contracting HIV. Eight volunteer couples — HIV-positive fathers and HIV-negative mothers — signed up to the trial, with one dropping out before it was paused.

He said there had been “another potential pregnancy” involving a second couple, but it is unclear whether that pregnancy is still ongoing.

Experts warned that editing human embryos can create unintended mutations in other areas — so-called “off-target effects” — which can have an impact through the lifetime.

Southern University of Science and Technology distanced itself from He, saying he had been on unpaid leave since February and had “seriously violated academic ethics”.

He, who was educated at Stanford University, said the twins’ DNA was modified using CRISPR, a technique which allows scientists to remove and replace a strand with pinpoint precision.

Co-creator of the technology Jennifer Doudna said she felt “horrified” at hearing He’s talk, adding she felt deeply concerned for the people affected and questioned whether they really understood the procedure.

Summit organisers said germline genome editing could become “acceptable” in future if rigorous criteria are met, including “strict independent oversight”.

However they added that there were too many scientific and technical uncertainties to permit clinical trials at this stage.

US life expectancy drops again as overdoses climb

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US life expectancy drops again as overdoses climb

Breaking News November 29, 2018 12:59

By Agence France-Presse
Tampa

Life expectancy in the United States dropped yet again as drug overdose deaths continued to climb — taking more than 70,000 lives in 2017 — and suicides rose, a US government report said Thursday.

The drug overdose rate rose 9.6 percent compared to 2016, while suicides climbed 3.7 percent, said the US Centers for Disease Control and Prevention’s (CDC) National Center for Health Statistics.

As a result, the average life span in America dropped to “78.6 years, a decrease of 0.1 year from 2016,” said the report.

The data comes as the United States grapples with a vast opioid epidemic, fueled by addiction to prescription painkillers as well as street drugs like heroin and synthetic opioids including fentanyl.

“The latest CDC data show that the US life expectancy has declined over the past few years. Tragically, this troubling trend is largely driven by deaths from drug overdose and suicide,” said CDC director Robert Redfield.

“Life expectancy gives us a snapshot of the nation’s overall health and these sobering statistics are a wakeup call that we are losing too many Americans, too early and too often, to conditions that are preventable.”

A ‘very concerning’ trend

Overdoses were a major factor when US life expectancy dropped slightly in 2015 for the first time in decades.

Another downtick was reported by the CDC in 2016, though those data were later revised to show a flat year, said Robert Anderson, chief of the mortality statistics branch at the NCHS.

Overall, the statistics show a “downward trend in life expectancy since 2014,” a time period in which Americans have lost 0.3 years of life, he told AFP, describing the trend as “very concerning.”

Anderson said declines like this haven’t been seen since the great flu pandemic of 1918 and World War I — though those losses were steeper.

The peak of the HIV/AIDS epidemic in the 1980s also saw a nationwide drop in life expectancy.

“We’re a developed country, we have a lot of resources, we should have increasing life expectancy, not decreasing life expectancy,” he added.

Canadians live on average three years longer than Americans. Japan has the longest life expectancy in the world, at almost 84.

‘Hard to digest’

Drug overdose deaths from synthetic opioids like fentanyl — which killed the musicians Prince and Tom Petty — and tramadol increased by 45 percent between 2016 and 2017.

The rate of heroin deaths was seven times higher than in 1999.

CDC figures showed that a total of 70,237 people died of overdoses in 2017.

Most of these deaths were unintentional in nature.

The rise — although dramatic at nearly 10 percent year-on-year — was about half the spike seen a year earlier.

In 2016, 21.6 percent more people died from overdoses compared to 2015.

Separately released preliminary government data for the first part of 2018 have also appeared to show a leveling off in overdose deaths.

Health and Human Services Secretary Alex Azar said at a health conference in October, when that data came out, that the “seemingly relentless trend of rising overdose deaths seems to be finally bending in the right direction.”

But experts urged caution in interpreting the results to mean the opioid epidemic has peaked, or is anywhere near an end.

“It is encouraging to see the trajectory of this start to decrease, without a doubt,” said Harshal Kirane, director of addiction services at Staten Island University Hospital in New York, who was not involved in the data collection.

“What would be a signal of some real change would be when the total number of overdose deaths year to year is actually decreasing,” he told AFP.

“Seventy-thousand deaths is hard to digest in any way as a positive outcome.”

Lakhon Khol gets Unesco Heritage status

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One performance of the Lakhon Khol. Pha Lina
One performance of the Lakhon Khol. Pha Lina

Lakhon Khol gets Unesco Heritage status

ASEAN+ November 29, 2018 11:37

By Khouth Sophak Chakrya
The Phnom Penh Post
Phnom Penh

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Unesco on Wednesday inscribed the traditional Cambodian dance drama genre Lakhon Khol on the List of Intangible Cultural Heritage in Need of Urgent Safeguarding in Port Louis, the capital of Mauritius, the Ministry of Culture and Fine Arts has announced.

Lakhon Khol’s successful Unesco registration was thanks to government attention, the efforts of leaders of the Ministry of Culture and Fine Arts, support from actors, organisations and civilians in the fine arts and culture sectors and encouragement from the public.

“Tangible and intangible heritage of our country have helped Cambodia to become well-known on the international stage and they are important players on the world heritage stage.”

“The decision to include Lakhon Khol in the world heritage list is a new pride for our nation,” the ministry said in its announcement.

Cambodia requested the registration of Lakhon Khol in the world heritage list on March 31 last year, and the committee approved the inscription during the 13th meeting on Wednesday.

The Cambodian delegation attending the meeting included Minister of Culture and Fine Arts Phoeurng Sackona, undersecretary of state of the Ministry of Foreign Affairs and International Cooperation Ket Sophann, government expert advisers Helen Jarvis and Teruo Jinnai and five Cambodian representatives at Unesco.

Lakhon Khol began in the early Angkor era. In accordance with bas-reliefs on Angkor temple walls, it is believed that the genre was first performed in the ninth century.

According to the book Inventory of Intangible Cultural Heritage of Cambodia, Lakhon Khol was developed as an entirely male version of Khmer classical court dance.

The only story specifically performed by Lakhon Khol is the Reamke, the Khmer version of the Ramayana, an ancient Indian epic poem.

Performances include storytelling accompanied by the traditional Pin Peat orchestra.

In the past, there were eight professional Lakhon Khol troupes but they were disbanded during the war and the only remaining troupe is that of Wat Svay Andet, 15km from Phnom Penh in Kandal province, where knowledge has been handed down from one generation to the next.

Two new troupes were formed since the war, in Kampong Thom and at the National Theater. Today, Lakhon Khol forms part of the curriculum of the Royal University of Fine Arts.

Peru ‘catastrophe’ feared after 8,000-barrel Amazon oil spill

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Peru ‘catastrophe’ feared after 8,000-barrel Amazon oil spill

ASEAN+ November 29, 2018 09:31

By Agence France-Presse
Lima

A Peruvian oil executive warned Wednesday of “catastrophe” after indigenous residents cut a major pipeline in a region of the Amazon, triggering the spill of 8,000 barrels of oil.

“We could face an environmental catastrophe,” Beatriz Alva, a manager with state oil firm Petroperu, told channel N television.

Alva gave the volume of spilled crude as “more or less 8,000 barrels.”

Residents in a remote community of Morona district, in the northeastern Loreto region, “cut the pipeline” on Tuesday night and prevented workers from repairing it, Alva said.

Residents of the district are overwhelmingly indigenous people.

Villagers had threatened last week to cut the pipeline, which moves crude from Amazonian wells to coastal refineries, in a protest against alleged irregularities in local elections held in October.

Peru’s Amazon region has seen repeated oil spills in recent years, some the results of a lack of maintenance. Others were caused by protest attacks.

The country produced 127,000 barrels of oil per day in 2017, according to the BP Statistical Review of World Energy.

US Navy ships sail through Taiwan Strait

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US Navy ships sail through Taiwan Strait

ASEAN+ November 29, 2018 06:46

By Agence France-Presse
Washington

Two US Navy ships sailed through the Taiwan Strait on Wednesday, the third such operation this year and one that is sure to anger China.

Lieutenant Rachel McMarr, a spokeswoman for the US Pacific Fleet, said the destroyer USS Stockdale and oiler USNS Pecos sailed through the strait in a “routine” transit.

“The ships’ transit through the Taiwan Strait demonstrates the US commitment to a free and open Indo-Pacific,” McMarr said in a statement.

“The US Navy will continue to fly, sail and operate anywhere international law allows.”

Beijing protested after the US Navy sailed two warships through the Taiwan Strait on October 22, characterizing the move as an affront to its sovereignty.

China still sees Taiwan as part of its territory to be reunified, despite the two sides being ruled separately since the end of a civil war on the mainland in 1949.

A US official told AFP that Chinese ships had asserted a “presence” during Wednesday’s sailing, but all interactions between the two navies were “safe and professional.”

Nations urged to accelerate efforts to beat malnutrition

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Nations urged to accelerate efforts to beat malnutrition

ASEAN+ November 28, 2018 14:47

By The Nation

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With rising levels of global hunger jeopardising the goal of ending malnutrition by 2030, the United Nations Food and Agriculture Organisation (FAO) and the International Food Policy Research Institute (IFPRI) are hosting a conference in Bangkok aimed at urgently accelerating efforts to achieve Zero Hunger.

After decades of impressive reductions in the numbers of undernourished people, hunger is again on the march. According to the latest report published jointly by FAO and four other UN agencies, 820 million people are malnourished.

“This is the third consecutive year that progress in ending hunger has stalled and now has actually increased,” said FAO Director-General José Graziano da Silva. “Child stunting is a major problem and nearly two billion still suffer from hidden hunger or a deficiency of important nutrients. This also includes people who are overweight or obese.”

While there are big challenges in reaching Zero Hunger, FAO and IFPRI are stressing that the goal is still achievable, said Shenggen Fan, IFPRI Director General.

“Many countries – from China, to Ethiopia, to Bangladesh to Brazil – have achieved remarkable reductions in hunger and malnutrition, and those successes hold important lessons for the places currently struggling to make significant progress.”

The conference, attracting delegates primarily from Africa and Asia is providing a platform to accelerate the sharing of existing knowledge and tools.

While Africa continues to be the hungriest continent per capita, the Asia-Pacific region has the highest total number of undernourished – more than 500 million by FAO estimates.

The region is home to more than 60 per cent of the world’s undernourished, and in order for it to achieve Zero Hunger by 2030, countries need to collectively lift more than 110 000 people out of hunger each and every day for the next 12 years.

Good public policy and knowledge are essential. At the conference, which continues through November 30, strides made in many countries, rapidly and sustainably, will be highlighted.

Bangladesh, for example, has achieved one of the fastest reductions in child underweight and stunting in history, largely by using innovative public policies to improve agriculture and nutrition. Policies supporting agricultural growth helped increase production, while other policies supported family planning, stronger health services, growing school attendance, greater access to drinking water and sanitation, and women’s empowerment.

Economic growth in China lifted millions out of both hunger and poverty, while Brazil and Ethiopia transformed their food systems and diminished the threat of hunger through targeted investments in agricultural research and development and social protection programmes.

Starting in the mid-1980s and continuing over two decades, crop production in Brazil grew by 77 per cent and that – combined with the country’s Fome Zero programme, established in 2003 to provide beneficiaries a wide range of social services – saw hunger and undernutrition nearly eradicated in just 10 years.

Similarly, Ethiopia’s large-scale investments in agricultural have led to substantial growth in the production of cereals and the availability of food, while the creation of the Productive Safety Net Programme provides food and/or cash to needy households, which are direct for the most needy and conditional on a work requirement for others.

The proliferation of new communications technologies, and ability to harness big data, also offer opportunities to scale up successes significantly to even greater impact.

But innovation extends far beyond apps, drones or farm machinery. Innovation in agriculture can involve using new social, organizational and institutional processes to support farmers and sustainably intensify production.

These can range from building stronger producer self-help groups and extension services, to improving access to markets and credit in pioneering ways, to developing new ways of processing, storage, transport and marketing food.

Innovation can be decidedly “low tech” – for example leaving stands of trees on farms intact to promote soil health and enhance agroecosystem productivity. Innovations in intervention design can boost their potential impact, like when behaviour change communications that encourage the adoption of ideal nutrition and child feeding practices are integrated into social protection programmes to improve household nutrition as well as food consumption.

“We have the tools, and we have the knowledge to eliminate hunger in the next 12 years,” said Fan. “By empowering key actors in policymaking, research, and program implementation with those tools and knowledge, we can reach this goal and help millions of people achieve their full potential.”

“We need to work closely together more than ever, sharing with each other those successful experiences,” Graziano da Silva said.

“If we can accelerate this knowledge exchange, then we can accelerate its implementation and take actions that are more concrete. Hunger and obesity are not simply an individual’s problem. They are public issues. But we also need stronger political will and greater financial commitment to get the job done. Political will is fundamental.”

Lion Air jet should have been grounded before fatal flight, Indonesia says

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Indonesia's National Transportation Safety Commission's (KNKT) deputy head Haryo Satmiko (2nd R) delivers a preliminary report on Lion Air flight JT 610 during a press conference in Jakarta on November 28, 2018./AFP
Indonesia’s National Transportation Safety Commission’s (KNKT) deputy head Haryo Satmiko (2nd R) delivers a preliminary report on Lion Air flight JT 610 during a press conference in Jakarta on November 28, 2018./AFP

Lion Air jet should have been grounded before fatal flight, Indonesia says

ASEAN+ November 28, 2018 13:49

By Agence France-Presse
Jakarta

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A Lion Air jet that crashed last month should have been grounded over a recurrent technical problem and never permitted to make the fatal flight, Indonesian authorities said Wednesday in a report that took aim at the carrier’s poor safety culture.

The Boeing 737 MAX vanished from radar about 13 minutes after taking off from Jakarta on October 29, slamming into the Java Sea moments after it had asked to return to the capital.

The preliminary crash report from Indonesia’s transport safety agency did not pinpoint a definitive cause of the accident, which killed all 189 people on board, with a final report not likely to be filed until next year.

But investigators said that Lion Air kept putting the plane back into service despite repeatedly failing to fix a problem with the airspeed indicator in the days leading up to the fatal flight.

Its second last flight was from Denpasar in Bali to Jakarta.

“During (that) flight, the plane was experiencing a technical problem but the pilot decided to continue,” Nurcahyo Utomo, aviation head at the National Transport Safety Committee, told reporters.

“The plane was no longer airworthy and it should not have kept” flying, he added.

The findings will heighten concerns there were problems with key systems in one of the world’s newest and most advanced commercial passenger planes.

Investigators have previously said the doomed aircraft had problems with its airspeed indicator and angle of attack (AOA) sensors, prompting Boeing to issue a special bulletin telling operators what to do when they face the same situation.

The report confirmed that initial finding, saying the plane’s data recorder detected an issue with the AoA.

It also said the plane’s “stick shaker” — the steering-wheel like handles in front of the pilots that vibrates to warn of a system malfunction — was “activated and continued for most of the fight.”

An AOA sensor provides data about the angle at which air is passing over the wings and tells pilots how much lift a plane is getting. The information can be critical in preventing an aircraft from stalling.

Dubious record

The Indonesian National Transportation Safety Committee has retrieved one of the plane’s black boxes — the flight data recorder — but is yet to locate the cockpit voice recorder.

Black box data showed the plane also had an airspeed indicator issue on multiple earlier flights, investigators said.

Lion must take steps “to improve the safety culture” and ensure “all the operation documents are properly filled and documented”, the transport agency said.

Despite a dubious safety record and an avalanche of complaints over shoddy service, the budget carrier’s parent Lion Air Group, which also operates Batik Air and Wings Air, has captured half the domestic market in less than 20 years of operation to become Southeast Asia’s biggest airline.

Indonesia’s aviation safety record has improved since its airlines, including national carrier Garuda, were subject to years-long bans from US and European airspace for safety violations, although the country has still recorded 40 fatal accidents over the past 15 years.

The report stopped short of making any recommendations to Boeing but the US planemaker has come under fire for possible glitches on the 737 MAX — which entered service just last year.

The APA, a US airline pilots union, said that carriers and pilots had not been informed by Boeing of certain changes in the aircraft control system installed on the new MAX variants of the 737.

“I am really surprised if Boeing has not shared all the flight performance parameters with pilots, unions, and training organisations,” University of Leeds aviation expert Stephen Wright told AFP before the report was released, adding that “a deliberate omission would have serious legal ramifications”

Several relatives of the crash victims have already filed lawsuits against Boeing, including the family of a young doctor who was to have married his high school sweetheart this month.

Lion Air Flight JT610 plunged into the sea less than half an hour after taking off on a routine flight to Pangkal Pinang city.

Authorities have called off the grim task of identifying victims of the crash, with 125 passengers officially recognised after testing on human remains that filled some 200 body bags.

Japan’s climate change plan approved by Cabinet

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Japan’s climate change plan approved by Cabinet

ASEAN+ November 28, 2018 08:39

By The Japan News
Asia News Network
Tokyo

The government approved a climate change adaptation plan at a Cabinet meeting on Tuesday that is aimed at countering the dangers caused by global warming, including disasters and the impact on farm produce, among other problems.

The adaptation plan — a revision of an earlier plan drawn up in 2015 — was compiled ahead of the December effectuation of the Climate Change Adaptation Law, which is aimed at creating a society that can keep up with the progression of global warming.

Global warming can be countered through mitigation, by reducing greenhouse gas emissions, and adaptation, by reducing the impact of global warming.

The new plan will make clear which measures will be carried out by which ministry or agency.

For developing countries that are susceptible to the effects of global warming, the government will also set up a framework to utilize Japan’s technological strength and scientific knowledge to forecast the impact in the Asia-Pacific region and support their efforts toward adaptation.

Accordingly, the government will set up a panel to promote adaptation with the participation of relevant ministries and agencies. The panel, to be headed by the environment minister, is scheduled to hold its first meeting on Dec. 3.

Govts already taking action

Ahead of the enforcement of the Climate Change Adaptation Law, the central government and local authorities are already taking steps to protect farm produce from such climate change-related phenomena as record-breaking torrential rain and extreme heat.

The city of Uwajima, Ehime Prefecture, was hit by landslides amid heavy rain in western Japan in July. “In recent years, droughts and heavy rain have intensified tremendously,” said Keiro Wada, chief of the city government’s agricultural and forestry section.

Shinji Ninomiya, a 38-year-old tangerine farmer in the city, saw his about 100-square-meter field of tangerine trees swept away by a landslide. Landslides have occurred three or four times in the last decade and it takes three years to produce the fruit from seedlings, Ninomiya said.

“We can’t prevent it from happening, because our field is on a mountain slope,” he lamented.

In an effort to prevent future damage, the city government and the prefectural government are considering a plan to build an agricultural park near the mountain summit, where there is little possibility a landslide will occur.

The Saitama prefectural government has developed Sai no Kizuna, a high quality variety of rice resistant to high temperatures. The rice plant is about 15 centimeters shorter than that of the well-known Koshihikari variety, making it resistant to typhoons.

Rice farmers have been able to produce Sai no Kizuna even in intense heat. “By continuing to make modifications, we hope to develop a variety that won’t be affected by weather,” said Makoto Arakawa, 49, of the prefecture’s Saitama Agricultural Technology Research Center.

In addition to developing varieties resistant to heat, the Agriculture, Forestry and Fisheries Ministry is checking the water retention capabilities of paddy fields as a measure to cope with heavy rain.

“If we can learn the amount of water that can be retained, inundation can be delayed, reducing damage to residential areas and elsewhere,” a ministry official in charge said.

The ministry is also studying how to strengthen soil layers, to prevent fertile soil from getting washed away by heavy rain.

A special report released by the Intergovernmental Panel on Climate Change (IPCC) in October stated that the world’s average temperature has already risen by about 1 C from the level before the Industrial Revolution.

If the warming continues, the figure could climb another 1.5 C between 2030 and 2052. The U.N. body has listed possible effects of global warming based on temperature increases.

“It’s important to implement measures that fully consider precipitation patterns and temperature fluctuations,” said Takasaki City University of Economics Prof. Takeshi Mizuguchi, who specializes in measures to counter global warming.

Syrian refugee stranded at Malaysian airport lands in Canada

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Syrian refugee stranded at Malaysian airport lands in Canada

ASEAN+ November 28, 2018 08:26

By Agence France-Presse
Ottawa

A Syrian refugee who spent months in limbo in a budget terminal at a Malaysian airport has arrived in Vancouver after he was granted permanent residency by Canada, a government source and his lawyer said Tuesday.

Hassan al-Kontar’s plight became widely known after he shared posts on social media that showed him surviving on donated airline meals, washing and giving himself a haircut in the toilets at Kuala Lumpur International Airport’s Terminal 2.

He had been stuck since March — blocked from entering Malaysia because of visa issues and barred from travelling to other countries, and was detained last month by immigration officials.

“I know I look like someone who ran from the stone or middle ages. I’m sorry for that,” the smiling 36-year-old said in a Twitter video Monday, looking tired and stroking his bushy beard.

“For the last eight years, it was (a) hard, long journey. The last 10 months, it was very hard and cold,” he added.

After Kontar’s arrest, Malaysian officials had said they were going to work with Syrian authorities to deport him back to his war-torn homeland.

But Kontar’s lawyer Andrew Brouwer said they brought the Syrian back to the Kuala Lumpur airport on Monday before he was put on a Vancouver-bound flight.

Brouwer said his client was recognised by Canada as a refugee and was granted permanent residency under the country’s refugee sponsorship programme.

“We were of course very pleased that Malaysia appeared to agree and abide by international law,” he said.

Malaysia’s immigration office said in a statement Tuesday it had held talks “on the basis of concern and humanity… with the embassy of the country that agreed to receive his relocation,” without naming Canada.

‘No more airports’

In the video on his Twitter account Kontar said he was in transit in Taiwan and that he would be reaching his “final destination” the following day.

“I could not do it without the support and the prayers from all of you,” he said.

In Vancouver, he was greeted by Laurie Cooper, who with the help of a group of residents in the ski resort of Whistler and the British Columbia Muslim Association, brought him to Canada and raised almost Can$15,000 for his fresh start.

Public broadcaster CBC said he looked “fragile in a blue T-shirt and jeans, his curly hair long and his beard unkempt” after disembarking.

“I’ve done my time in airports, no more airports,” he told the network after a sleepless flight across the Pacific.

“In Canada, here you have something very special, you have an amazing group of people who believe they can make a difference, and they can.”

Looking at Cooper, he said: “When I was thinking of hope, her face was coming to my mind.”

Before climbing into a car and heading to Whistler, where a bed, fresh clothes and a hotel job were awaiting him, he whispered to himself: “I will be fine.”

Kontar is not the only asylum seeker who has been left in limbo at an airport for a long period of time.

In 2015 an Iraqi family spent more than two months in an empty smoking cubicle in a Moscow airport, relying on passengers to bring them food and water.

Kontar’s case also recalls the 2004 film “The Terminal,” in which Tom Hanks plays a man who finds himself stuck in a New York airport after his government collapses, rendering his papers useless.

Millions of Syrians have fled a devastating seven-year civil war that has left more than 350,000 people dead.

Trump attacks Fed chief, ‘not even a little bit happy’ with Powell

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Trump attacks Fed chief, ‘not even a little bit happy’ with Powell

ASEAN+ November 28, 2018 06:53

By Agence France-Presse
Washington

President Donald Trump once again blasted his hand-picked chief of the US central bank Tuesday, saying he was “not even a little bit happy” with his selection of Jerome Powell.

The Federal Reserve chairman has presided over three interest rate increases this year, and in an interview with The Washington Post Trump said the Fed is “way off base.”

“They’re making a mistake because I have a gut and my gut tells me more sometimes than anybody else’s brain can ever tell me,” the president added.

Trump named Powell to take over the helm of the Fed at the start of the year, but has repeatedly attacked him for continuing to raise the benchmark lending rate, which he says undermines the work he is doing to juice the US economy.

“I’m doing deals and I’m not being accommodated by the Fed,” Trump said.

The Fed is expected to raise the key rate again in December as it works to keep inflation from accelerating beyond the two percent target, amid a strong job market that has pushed unemployment to a 50-year low of 3.7 percent.

Powell and other officials have repeatedly dismissed the unprecedented political attacks from Trump, saying they have no impact on policy deliberations of the independent central bank.